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Furthermore, these studies were rather small-scaled with short duration and design flaws were apparent

This enormous safety margin explains why serious adverse effects remain essentially unreported in the research literature

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Across the various development stages, from Phase I to pre-registration, 101 different companies have contributed at least one novel drug candidate to the development pipeline, (Figure 3 a), indicative of the perceived opportunity that continues to exist in the medical management of obesity

172 Genes involved in pathways related to oxidative stress and antioxidant defense might therefore be potential genetic modifiers in AATD-related liver diseases, and warrant further investigation

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